Adenosine-5′-diphosphate (ADP) plays a key role in platelet function (see Chapter 10).Although ADP is a weak platelet agonist, when it is secreted from the platelet dense granules where it is stored, ADP amplifies the platelet responses induced by other platelet agonists. The net reaction for the overall process of Steps 1 and 3 require the input of energy derived from the hydrolysis of ATP to ADP and PAdenosine 5′-diphosphate; Adenosine 5′-pyrophosphate; Adenosine pyrophosphateInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1InChI=1/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1O=P(O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n2cnc1c(ncnc12)N)[C@H](O)[C@@H]3Oc1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)O)O)O)NExcept where otherwise noted, data are given for materials in their Adenosine diphosphate (ADP) receptor inhibitors are a drug class of antiplatelet agents, used in the treatment of acute coronary syndrome (ACS) or in preventive treatment for patients who are in risk of thromboembolism, myocardial infarction or a stroke. Some studies have shown interindividual differences in ADP-induced platelet aggregation responses ex vivo, but the mechanisms underlying this variability are unknown. ScienceDirect ® is a registered trademark of Elsevier B.V.URL: https://www.sciencedirect.com/science/article/pii/B9780123693679508235URL: https://www.sciencedirect.com/science/article/pii/B9780128134566000096URL: https://www.sciencedirect.com/science/article/pii/B9780123693679507886URL: https://www.sciencedirect.com/science/article/pii/B9780323357623001256URL: https://www.sciencedirect.com/science/article/pii/B9780128126158000041URL: https://www.sciencedirect.com/science/article/pii/B9780123878373000195URL: https://www.sciencedirect.com/science/article/pii/B9780123842602500101URL: https://www.sciencedirect.com/science/article/pii/B9780123693679507722Pathologic Basis of Veterinary Disease (Sixth Edition), 2017The Role of Platelets in the Pathophysiology of Atherosclerosis and Its ComplicationsMelanie McCabe White B.A., ... Michael P. Condry, in ScienceDirect ® is a registered trademark of Elsevier B.V. Background: The adenosine diphosphate (ADP) receptor P2Y12 plays a pivotal role in platelet aggregation, as demonstrated by the benefit conferred by its blockade in patients with cardiovascular disease. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. Under normal conditions, small disk-shape platelets circulate in the blood freely and without interaction with one another. This leads to a decrease in aggregation of platelets, prohibiting thrombus formation. ADP was one of the earliest identified platelet agonists, but ADP receptors were only identified much later.ADP is a key platelet agonist that functions by binding to G protein coupled receptors, P2Y1 and P2YADP is an important primary platelet agonist and also amplifies other primary responses following its secretion from platelet dense granules. It is also released from damaged cells at sites of vascular injury, serving as an autocrine and paracrine stimulus for recruiting additional platelets and stabilizing the hemostatic plug. For this reason, biological processes have evolved to produce efficient ways to replenish the potential energy of ATP from ADP.Breaking one of ATP's phosphorus bonds generates approximately 30.5 Glycolysis is performed by all living organisms and consists of 10 steps. ADP is stored in dense bodies inside blood platelets and is released upon platelet activation. ADP binding to P2Y1 (~150 copies per platelet), which is coupled to the α subunits of GATP is an antagonist of P2Y1 and P2Y12, but an activator of P2X1, a ligand-gated ion channel, that causes rapid influx of CaADP is a platelet agonist that interacts with platelet purinergic P2 receptors, including P2YADP is stored in platelet dense granules and released upon platelet activation. Adenosine diphosphate (ADP) released from platelet dense granules triggers the binding of fibrinogen to platelet receptor GPIIb-IIIa, resulting in the formation of fibrinogen bridges that link platelets into a loose aggregate.Adenosine-5′-diphosphate (ADP) plays a key role in platelet function (see ADP is an important primary platelet agonist and is also a critical autocrine via secretion from platelet dense granules.


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