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Signs and symptoms of DCM Dilated cardiomyopathy can appear along a spectrum of no symptoms, subtle symptoms or, in the more severe cases,

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entiate TCMP from irreversible dilated cardiomy-opathy. dilated cardiomyopathy (IDC). /Height 960 3 0 obj endobj /Length 13 0 R

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© 2020 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA) endstream /ca 1.0 >> endobj In this chapter, we review our current understanding of the cardiomyopathies with a focus on the genetic mutations and molecular pathways implicated in their pathogenesis. /SMask 6 0 R

While previously conceived as the general sequelae of ischemic heart disease or extrinsic insults, familial studies have greatly facilitated our understanding of the molecular basis for the cardiomyopathies.

/Creator (�� w k h t m l t o p d f 0 . stream /SMask /None>> Dilated cardiomyopathy has many known and probably many unidentified causes (see table Sudden emotional stress and other hyperadrenergic states can trigger acute dilated cardiomyopathy that is typically reversible (as is that caused by prolonged tachycardia). /CA 1.0 Dilated cardiomyopathy is defined by the presence of left ventricular dilatation and contractile dysfunction.

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6 0 obj /Type /XObject << /ColorSpace /DeviceGray Other interventions include /SM 0.02

DCM usually affects both the left and right sides of the heart. Calculators (0) /Type /ExtGState 12 0 obj

/Height 1048 Dilated cardiomyopathy (DCM) is best understood as the final common response of myocardium to diverse genetic and environmental insults. Developed in collaboration with the Heart Failure Association (HFA) of the ESC.Diuretic strategies in patients with acute decompensated heart failure.Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial.Acute decompensated heart failure: update on new and emerging evidence and directions for future research.Angiotensin-neprilysin inhibition versus enalapril in heart failure.Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). Tables (1)

Randomized Aldactone Evaluation Study Investigators.Eplerenone in patients with systolic heart failure and mild symptoms.Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study.Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure.Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure.The effect of cardiac resynchronization on morbidity and mortality in heart failure.Cardiac-resynchronization therapy for mild-to-moderate heart failure.Defibrillator implantation in patients with nonischemic systolic heart failure.Long-term use of a left ventricular assist device for end-stage heart failure.Advanced heart failure treated with continuous-flow left ventricular assist device.Should we SHIFT our thinking about digoxin?

sarcomere, and nuclear envelope proteins, among others, account for up to 35% of cases.

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