Despite higher phagocytic activity, CD16+ monocytes occurred in our patients with SA and SLE but not in those with TB; they produced huge amounts of pro-inflammatory cytokines, mostly TNF-α, IL-1, IL-6, IL-12 and IL-17, and expressed higher levels of HLA-promoting persistent inflammation and/or autoimmunity26 (reviewed by Dubaniewicz et al.31). Name:CD16 Imported. 1e4j: CRYSTAL STRUCTURE OF THE SOLUBLE HUMAN FC-GAMMA RECEPTOR III, 1e4k: CRYSTAL STRUCTURE OF SOLUBLE HUMAN IGG1 FC FRAGMENT-FC-GAMMA RECEPTOR III COMPLEX, 1fnl: CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII, 1t83: CRYSTAL STRUCTURE OF A HUMAN TYPE III FC GAMMA RECEPTOR IN COMPLEX WITH AN FC FRAGMENT OF IGG1 (ORTHORHOMBIC), 1t89: CRYSTAL STRUCTURE OF A HUMAN TYPE III FC GAMMA RECEPTOR IN COMPLEX WITH AN FC FRAGMENT OF IGG1 (HEXAGONAL), GRCh38: Ensembl release 89: ENSG00000162747, GRCm38: Ensembl release 89: ENSMUSG00000059089, "Entrez Gene: FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)", "Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG", "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms", "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. ©2020 Novus Biologicals, All Rights Reserved. Initial molecular studies on CD16 used the CD16 antibody to characterize ligand and receptor binding sites and assist in molecular modeling1. The lack of inhibitory receptors can even result in more effective ADCC responses by noneducated NK cells compared to their educated counterparts (Tarek et al., 2012). CD16 is a lymphocyte Fc gamma type III low-affinity receptor for IgG and is represented by two similar genes, CD16A (Fc gamma RIII A) and CD16B (Fc gamma RIIIB). Copyright © 1996-2020 , Weizmann Institute of Science. Further studies from this group have shown that these alveolar lymphocytes are characterized by expression of CD57, and that suppression of CTL activity is mediated by a lectin-binding soluble factor (Sadat-Sowti et al., 1991, 1994). [1] CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), which participate in signal transduction. However, recent findings suggest that slan DCs are indistinguishable from CD16+ monocytes (Cros et al., 2010). FcγRIIIa and FcγRIIIb together are able to activate degranulation, phagocytosis, and oxidative burst, which allows neutrophils to clear opsonized pathogens. CD16A exists as a heterooligomeric polypeptide-anchored form in macrophages and NK cells. As a result of this nonproductive degranulation, NK cells become exhausted and show a lower cytotoxic activity after IVIg exposure in vitro and in vivo (Jacobi et al., 2009). Bispecific antibody fragments, such as anti-CD19/CD16, allow the targeting of immunotherapeutic drugs to the cancer cell. ; Evidence={ECO:0000305}; Sequence=BAD97015.1; Type=Erroneous initiation; Note=Extended N-terminus. [4] In addition, FcγRIIIb is the only Fc receptor anchored to the cell membrane by a glycosyl-phosphatidylinositol (GPI) linker, and also plays a significant role in triggering calcium mobilization and neutrophil degranulation. CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophils, monocytes, and macrophages. CD16 is a low affinity Fc receptor for IgG and is responsible for antibody-dependent cellular cytotoxicity (Lanier et al., 1983; Perussia et al., 1983). deHaas’ group from the Netherlands relied upon the CD16 antibody to assess the implications of polymorphisms in the CD16A gene among a donor pool2. Sarah Rowland-Jones, ... Andrew McMichael, in Advances in Immunology, 1997. However, this pathway can also be targeted in cancerous or diseased cells by immunotherapy. CD16 is the type III Fcγ receptor. lentivirus, AAV, adenovirus), Search GeneCopoeia for miRNA 3'UTR Target clone products for FCGR3A, Browse OriGene Inhibitory RNA Products For FCGR3A, Search Santa Cruz Biotechnology (SCBT) for FCGR3A siRNA/shRNA, Clones for FCGR3A - Select products 50% OFF >, Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling, Human Fc gamma RIIIA/CD16a (NP_001121065) VersaClone cDNA (RDC1341), Browse ESI BIO Cell Lines and PureStem Progenitors for FCGR3A, VectorBuilder Stable cell line generation for FCGR3A, Natural killer cell mediated cytotoxicity, Regulation of actin dynamics for phagocytic cup formation, Fcgamma receptor (FCGR) dependent phagocytosis, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Natural killer-like cells(Woll PS et. CD16 function is a low affinity IgG receptor mediating antibody-dependent cellular cytotoxicity (ADCC) by NK cells and was also demonstrated to directly recognize unknown tumour ligand (Mandelboim et al., 1999). [10], CD16 is often used as an additional marker to reliably identify different subsets of human immune cells. This gene is overexpressed in Whole Blood (x20.1) and Spleen (x6.7). Additionally, Gasdaska et al used the CD16 antibody in their characterization studies of a novel afucosylated rituximab (BLX-300)3. A population of CD8+ HNK1+ CD4− CD16− T cells was identified among the alveolar lymphocytes of AIDS patients (Joly et al., 1989) that were able to inhibit the activity of HIV-specific CTLs as well as CTLs against HLA-alloantigens in a non-MHC-restricted manner. CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophils, monocytes, and macrophages. Specifically, the structure of CD16 (FcγRIIIb) consists of two immunoglobulin-like domains, with an interdomain hinge angle of around 50°. Their expression is constitutive, although cytokines and lymphokines can modulate their expression levels.

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